	   SnapGene      ñgacggatcgggagatctcccgatcccctatggtcgactctcagtacaatctgctctgatgccgcatagttaagccagtatctgctccctgcttgtgtgttggaggtcgctgagtagtgcgcgagcaaaatttaagctacaacaaggcaaggcttgaccgacaattgcatgaagaatctgcttagggttaggcgttttgcgctgcttcgcgatgtacgggccagatatacgcgttgacattgattattgactagttattaatagtaatcaattacggggtcattagttcatagcccatatatggagttccgcgttacataacttacggtaaatggcccgcctggctgaccgcccaacgacccccgcccattgacgtcaataatgacgtatgttcccatagtaacgccaatagggactttccattgacgtcaatgggtggactatttacggtaaactgcccacttggcagtacatcaagtgtatcatatgccaagtacgccccctattgacgtcaatgacggtaaatggcccgcctggcattatgcccagtacatgaccttatgggactttcctacttggcagtacatctacgtattagtcatcgctattaccatggtgatgcggttttggcagtacatcaatgggcgtggatagcggtttgactcacggggatttccaagtctccaccccattgacgtcaatgggagtttgttttggcaccaaaatcaacgggactttccaaaatgtcgtaacaactccgccccattgacgcaaatgggcggtaggcgtgtacggtgggaggtctatataagcagagctctctggctaactagagaacccactgcttactggcttatcgaaattaatacgactcactatagggagacccaagcttggtaccgagctcggatccgccaccatgaccacaacaaggtaccggcccacctgggacctggccctcgacccgctggtgtcttgcaagctctgtcttggggagtacccagtggagcagatgacaaccatagcccagtgccaatgcatcttctgtactctgtgcctgaaacagtatgttgagctcttgatcaaagaaggattagaaaccgcaattagctgcccagatgctgcctgccctaaacagggccacctacaggagaacgagattgagtgcatggttgcagctgaaattatgcaaagatataaaaagctacaatttgaaagagaggtgctgtttgatccctgtcggacttggtgcccggcgtccacctgccaagctgtgtgtcagctccaggacgtggggctgcagaccccccagccagtgcagtgcaaagcctgccgtatggaattctgctccacctgcaaagccagctggcaccctggccagggctgcccggagaccatgccgatcaccttcctccccggggagaccagtgctgctttcaaaatggaagaagatgacgcgcccatcaagcgctgccccaagtgcaaagtctacatcgagcgagacgaaggctgcgcgcagatgatgtgcaagaactgcaagcacgccttctgctggtactgcctggagtctctggacgatgatttccttctgatacactacgataagggaccctgccggaacaagctgggccactcccgggcatctgtgatctggcatcggacacagggatccaccctgtctccatccctgggaaggtctactcctccttcaagacccagctcatgcagtagcccctgtgggaagcctttctcagtctcctcctcaccccacgtttggctgttgggaaaccactccgctttgtactttctgatgcaggattacaaatgtgtctatcactccccggaattgagtattggctctggagggcagaaaGAATTCTACCCATACGACGTACCAGATTACGCTtgactcgagcatgcatctagagggccctattctatagtgtcacctaaatgctagagctcgctgatcagcctcgactgtgccttctagttgccagccatctgttgtttgcccctcccccgtgccttccttgaccctggaaggtgccactcccactgtcctttcctaataaaatgaggaaattgcatcgcattgtctgagtaggtgtcattctattctggggggtggggtggggcaggacagcaagggggaggattgggaagacaatagcaggcatgctggggatgcggtgggctctatggcttctgaggcggaaagaaccagctggggctctagggggtatccccacgcgccctgtagcggcgcattaagcgcggcgggtgtggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcccgctcctttcgctttcttcccttcctttctcgccacgttcgccggctttccccgtcaagctctaaatcggggcatccctttagggttccgatttagtgctttacggcacctcgaccccaaaaaacttgattagggtgatggttcacgtagtgggccatcgccctgatagacggtttttcgccctttgacgttggagtccacgttctttaatagtggactcttgttccaaactggaacaacactcaaccctatctcggtctattcttttgatttataagggattttggggatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaacgcgaattaattctgtggaatgtgtgtcagttagggtgtggaaagtccccaggctccccaggcaggcagaagtatgcaaagcatgcatctcaattagtcagcaaccaggtgtggaaagtccccaggctccccagcaggcagaagtatgcaaagcatgcatctcaattagtcagcaaccatagtcccgcccctaactccgcccatcccgcccctaactccgcccagttccgcccattctccgccccatggctgactaattttttttatttatgcagaggccgaggccgcctctgcctctgagctattccagaagtagtgaggaggcttttttggaggcctaggcttttgcaaaaagctcccgggagcttgtatatccattttcggatctgatcaagagacaggatgaggatcgtttcgcatgattgaacaagatggattgcacgcaggttctccggccgcttgggtggagaggctattcggctatgactgggcacaacagacaatcggctgctctgatgccgccgtgttccggctgtcagcgcaggggcgcccggttctttttgtcaagaccgacctgtccggtgccctgaatgaactgcaggacgaggcagcgcggctatcgtggctggccacgacgggcgttccttgcgcagctgtgctcgacgttgtcactgaagcgggaagggactggctgctattgggcgaagtgccggggcaggatctcctgtcatctcaccttgctcctgccgagaaagtatccatcatggctgatgcaatgcggcggctgcatacgcttgatccggctacctgcccattcgaccaccaagcgaaacatcgcatcgagcgagcacgtactcggatggaagccggtcttgtcgatcaggatgatctggacgaagagcatcaggggctcgcgccagccgaactgttcgccaggctcaaggcgcgcatgcccgacggcgaggatctcgtcgtgacccatggcgatgcctgcttgccgaatatcatggtggaaaatggccgcttttctggattcatcgactgtggccggctgggtgtggcggaccgctatcaggacatagcgttggctacccgtgatattgctgaagagcttggcggcgaatgggctgaccgcttcctcgtgctttacggtatcgccgctcccgattcgcagcgcatcgccttctatcgccttcttgacgagttcttctgagcgggactctggggttcgaaatgaccgaccaagcgacgcccaacctgccatcacgagatttcgattccaccgccgccttctatgaaaggttgggcttcggaatcgttttccgggacgccggctggatgatcctccagcgcggggatctcatgctggagttcttcgcccaccccaacttgtttattgcagcttataatggttacaaataaagcaatagcatcacaaatttcacaaataaagcatttttttcactgcattctagttgtggtttgtccaaactcatcaatgtatcttatcatgtctgtataccgtcgacctctagctagagcttggcgtaatcatggtcatagctgtttcctgtgtgaaattgttatccgctcacaattccacacaacatacgagccggaagcataaagtgtaaagcctggggtgcctaatgagtgagctaactcacattaattgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgccagctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtattgggcgctcttccgcttcctcgctcactgactcgctgcgctcggtcgttcggctgcggcgagcggtatcagctcactcaaaggcggtaatacggttatccacagaatcaggggataacgcaggaaagaacatgtgagcaaaaggccagcaaaaggccaggaaccgtaaaaaggccgcgttgctggcgtttttccataggctccgcccccctgacgagcatcacaaaaatcgacgctcaagtcagaggtggcgaaacccgacaggactataaagataccaggcgtttccccctggaagctccctcgtgcgctctcctgttccgaccctgccgcttaccggatacctgtccgcctttctcccttcgggaagcgtggcgctttctcaatgctcacgctgtaggtatctcagttcggtgtaggtcgttcgctccaagctgggctgtgtgcacgaaccccccgttcagcccgaccgctgcgccttatccggtaactatcgtcttgagtccaacccggtaagacacgacttatcgccactggcagcagccactggtaacaggattagcagagcgaggtatgtaggcggtgctacagagttcttgaagtggtggcctaactacggctacactagaaggacagtatttggtatctgcgctctgctgaagccagttaccttcggaaaaagagttggtagctcttgatccggcaaacaaaccaccgctggtagcggtggtttttttgtttgcaagcagcagattacgcgcagaaaaaaaggatctcaagaagatcctttgatcttttctacggggtctgacgctcagtggaacgaaaactcacgttaagggattttggtcatgagattatcaaaaaggatcttcacctagatccttttaaattaaaaatgaagttttaaatcaatctaaagtatatatgagtaaacttggtctgacagttaccaatgcttaatcagtgaggcacctatctcagcgatctgtctatttcgttcatccatagttgcctgactccccgtcgtgtagataactacgatacgggagggcttaccatctggccccagtgctgcaatgataccgcgagacccacgctcaccggctccagatttatcagcaataaaccagccagccggaagggccgagcgcagaagtggtcctgcaactttatccgcctccatccagtctattaattgttgccgggaagctagagtaagtagttcgccagttaatagtttgcgcaacgttgttgccattgctacaggcatcgtggtgtcacgctcgtcgtttggtatggcttcattcagctccggttcccaacgatcaaggcgagttacatgatcccccatgttgtgcaaaaaagcggttagctccttcggtcctccgatcgttgtcagaagtaagttggccgcagtgttatcactcatggttatggcagcactgcataattctcttactgtcatgccatccgtaagatgcttttctgtgactggtgagtactcaaccaagtcattctgagaatagtgtatgcggcgaccgagttgctcttgcccggcgtcaatacgggataataccgcgccacatagcagaactttaaaagtgctcatcattggaaaacgttcttcggggcgaaaactctcaaggatcttaccgctgttgagatccagttcgatgtaacccactcgtgcacccaactgatcttcagcatcttttactttcaccagcgtttctgggtgagcaaaaacaggaaggcaaaatgccgcaaaaaagggaataagggcgacacggaaatgttgaatactcatactcttcctttttcaatattattgaagcatttatcagggttattgtctcatgagcggatacatatttgaatgtatttagaaaaataaacaaataggggttccgcgcacatttccccgaaaagtgccacctgacgtc  7ã      $            !                     !      *                                        !                                                                        "   '      "      0      #   .      #      +            !                                 $               "   "   2                                                                                                                                    !         &            !                  %   !   ,                                                                                  '   #         %   "                           '                                                                  &   +             $      !                  $               (      !   ,                     "         "      (         
   ,   )            &               *      *         šÞˆIJKPUde†´½¾b	;
�5ø5·ÕBÄx´Æ$  š1›½Ùo²ß‰D€˜Éõfo‡3
<
Ö-š¸CÅÂ�mwD · °LQ¿èp	¢	�
;‹6ÖyŒÇ Ø �pcYdG†V‘µc	µ	VŽê)6ùÒ†X
qÍµL 	 d -¾pàì|lŠDgÞ	­¹×?ÅDn! 9¢O™Êö1øp¦
~
•
Þ
Ëa�¿Ðõ{Ãø‰É¦-EU  ‡œŠA�jˆ4
=
ìþ;Çà1t¦¹Æ¨�Xž¹xÅŸ ›´2Ú³Ø#Ey[ô	Æé” .›]Ì ±eÈÄÞü9MRŽéî£	�
Ù
<²^Œ×Lò›±+R. E¿~£Àì–«å;Uz�×%e ¸ mŽ‘ñq	©	É	L
+–7‚ð5L³.z¯î�È  g �
Ò��øz¥Þ¼! ½ ‚å£×å�ë*y,D‘ÈËvIY�¨OnË˜ŠVl¶M � Ï@sÊVesHW~d	†	ª
®
ö
WÌ7m Jô1* • U6Qdâî>’š¶I	¡
ê
e°ÂDLg€ÔÝk|�ú‡¬Ó‡¢‰¿r§j Ù L©¹q^Z‡¶	D
‚ˆ¼3áhƒ7åð´~ÎÙ e ÂE„h¡€†«®ºBÊ/GJŽo 
 ?q}ƒÀm‹Úø@ZaE«—GÕ n .¿á‰74ß	ÆáJ¤ÿ÷�1] y -„í/Öw¦W
˜Ø·»ðÂ)pºå’Ý-ŠÒ"›  © >£¦ßšËùq²
ú
£-Ìí¿À|Ä¬ÉèaÚÊÙÏ. Y"G›¼÷L §–
ß
\ªb<~–ÑRùPŽ§¹V¶Ü ¬ :2Pq

ºUÎŽ2¾IF^« AùP«
¾ÕöŠ� 8 Ñ hò\©íð'‰¦	ÿpoÈáG§á Þ ˆ¨5?Â	¶Çg©_h�y  ð �B…*hkw	�	*
5
>
\
 uûci‚EŸ­®!    ‹7Îxn‚¯íò<ŠÛä2ªºYdlºÆ/„–ÄÆ×û   r~§ú´þ¬Ü$_Æ	Ø	Ççê)Mœ*=ê ž ê õz\tú`¡YZÍP " ÷ œµ3“ÛdÙr¹õ	iR}/s^_O* š Yd)s˜´Ào�F¯ò 	Ž	¥©Ÿ=•×AEd˜)™Y ²…ê
ÇNS�ìï³	ò	|
“
Ü
=Û_��3MÉ¯²,‡ÜP flþ¤	©;´”ãÛ(/  ] _ ÜÉøú!•:êƒ
…
‘
Ú
y�’ÊóZSàN s ‹Åß"'’Æó½çý}	³ý0ãØ!‡œ…£šïá p ¾6Ò°	¦âõ•&\ FŽÀëyÌ¬û<V{ùÒä L �ÞN(59Áµ
ý
Þ`íJZS—æ‘ÑØïfP¯ * Ô Óì#Dw¤ãbÁ3 a ç ,’òÇÕÛ	©ƒ0úH8; ÈÖ_Ò[ C ¹ ü 7òM
‹
ñœ´ï˜
&�°âïŽ À n�ÁÅÊêØÊ		“Ý6‹Mq/7Ý-a 0…B	r	ª	ç	ü	N,{—î!8È…“îü ¦={­ÝÉ  h èÕØ8a‚ùW^ uªýT·ü—<S	‡
Î
„ 	D‚F¦UË?o ¦ ËÙÍŒžØ#0
ÓVE{4û” èá	š
ã
#®:°Lß½ kŒ	Œ¤ÕãæÒwz’É+µ@J�”©™)­T� w Ï Øo
+¨¹-EÌK�PŒ-•‹W·N ¾ å 5ƒæüì§wøQoÇm" u Å ¯ºæèËØá÷		ˆ�Ðõÿ³ý>Z{‰Ì0ÞKÔ1‚Î' ÐAt*ï•$ê»IX{ù«
¯
ó
÷
}(ŠÃÍ÷8 äÍnq‡?BMÖÝõŒ { ‘ ÐM£)JÈõþ`¹
Ò
Érýßê;Š·ä3¥$2<" > ¥ �fty}&+Úe	¾
Â

€²ò!(Ã*/Ký‚ ËW‡	$X½!øñÐ0 k Ç VÅT_˜ÇõSe”¼ãVï¬ƒ±Y
fh�Þú l}ˆ¼Ô£Âˆ'xŠß-å"‡Ï † Z7²¢	šEMÕ#�™­lçžÀD# Y – ² Ê JRz—n›(	J		±ÃÚ7†NlÄÛåˆçr
d¡Îsk . 3 R /†Ô1 Aµ?¨“·	X	¢
ë
ÐkÿQûõ£ÿ\l}�@‹Ù à‚ ¨Zu´bœ ; 2uLF	ƒ‰4sv2WÏRi„òrŸ¼žÆÏ	Ú9# H Ú “ç�rðO_[ÊÎÿ	=	·	âY#8æñgtëÂ">„ã Qb.Î´¿éE
Œ’½J
uÑÚ´2µKð+ #M]kÇðöªºÿWfáh±¿ÁˆÜÍ		½	Ñ	(4=IS^’µ—%PÏ"%h ¶ ™nobCF…c¼o	¡	2
Ž
Œ÷ÃœpÌCK‹Å @{Zi¬ýÅ:ß0ŸÏô\€ËW¸Ä, f ¢Ãœû8Ø
*�Kä÷�! � ” ¼ á}¢ 
©
­
é
õ
�‡¯»ÁCËH§äïm—I‰0 ,>¿Áƒ¥÷AïÁoFI‰£þ « @=F~¥øKOª±
ù
¢[½ÔÈO`ØÎHŽµ  Ý ñ[„§¨ìgbfDc¬Å^­Ö rnŒÛ®sÅ	ù_¤Y˜ r ÛéŠ!&‘Å”|	²	ñ	¨/Éâ®†„ÛßM™à ) K o �Òë"Cvâ'½85´
ü
¥_ÐîøÑ2 B û /ÀÆŠ
M Ç/í¥î Ü	G%,ŽÕ^Ü S¥Ì×à	™
Í
â
"EKú> ‹¹×Ôàû		‡Ï§¸¦*J²“Æ‹(,Ó¬œ z )îx_z½
Ñ
ò
¼ñüÂÞé.p†>A¶÷‹#�$ … .y…Ó0S—±ôÿRU´§°W	X
™ÏÙùÃækq‡æ&œ~t³ G "þ-NÀÍ³ÍÎ»Ð$sêÁÅ Ž “ ¡?àB›úb1
€¦ãî ÊV›·ËˆÃ/BJ ª <¦¾¤§÷­Nr©ö£îÀÓeXý_b Úê¤ÄË˜
³
á
û
¤.^ÈD­ÛíÚÐÔ=˜ß" F „ (xÒ°ó,M¸ TÌßV	¼
Î¦ÍIûÁÏ}Åé=«€" ;¥¯½+LÊM¨—
»
à
Í]úÇÎ¥ÒâíÿdüU¶ìª—AÞ2 } Ðã­®�”	•	–	P
Q
R
d
e
ËÌcáìýþ67úûQRST�´µÔÕ§¨©–¨º&'4>?@·¸Ý ~ H	ÑäZœžž!]	S
f
d=ö
—8ÏÖâ5W¹Á Â#Hkø—	
«>S�û¼©»(½  I{­ 
~ºå	ŸŸT
€
»teÏ>íGÞ/Ö×Œ6X¬ x–_wî	V÷ÿ®¹)Jr|G_vºÂ  ¡ [O�·;3Q"g
r
v
É
m˜©ôÐ . ­ Ò^	c�{3¿9ãç a�Ö€l
;Ê‹5�ª ‹ íž$lQ

a
\¬³Ö})¾ >Ãð:ú˜	
.C¿	Ø?ê>¹‘übæ�¼÷ BøIù¬
Ô
T÷TP½9æ  +J®/c»�7 ˜§	ciÉB\fÐîhìò § |'–óªî(U
 P¼â?|¨ß0©Øõ�”™ Ò ƒæ*ñ�
HTÙ“žâY­ 9 åi
]¡s¹{ �Š·
À
ÿ
{qpu#HÀ×R7 @  ‹—‰lü’xÃ	ï	 ¤ …E*K‰Ã <y&«@/
ëøÅÈb`ºÿzH» ß ')ã$©àW·ñów¥ á `6[‚\¶¯hªi�s}`f¡ ¢ í ô o¤÷±û†4;#-lI
!&¹á™õUA£|‘ ñ ÿ P]\CPžiÜž	s
Ê
ñ,ƒF®Ñÿy € ¹ž¸+x	+
6
?
]
h
nwædÓ 8¯„§±Ô <R�?D"
w
W�H›vüj*ªpB  WVÓv(_	º	dØ¯´zï�4:BdMÅ  	×à{Ó8yµ'°ófÜôYœ\DQ|™À1±ä³…å ˆ   / N ® HhoÑ
Ä
î=Gå3»LèÚZm»è'0zÇü  ŒÏƒ’Ãg	8âb‹«Ÿ·7eÇAìö—Ø  Ö C½˜×„	Ç	è*ê±½vkuS bb�Ý%=]Èåë_¸+]Œf‚ s¨ûLµè`@	®	Ù	å	¿–6«ë ã ‘îÿ­lÉõm
&„N�<Ë>ÝI€žX %my}]û]»Z~¡ÎG* , ‰ Œ Ÿ îœŸöµRu	
b
Zaô§±4¿ ë :Õ%FyÑ­¢´ï×’‡£Ò 8{	
¯[ÃQ ÄGNûº
SÀ
~%pjwú
+ø ø ¶;i:j_?ºÅc ?�Ë4<ÜÚ			™	Ù`ýç‘ # ”ñe^¢ý*sö	
/DÃ0@ët¡’Pè5½ëbh › Z�¦J	¦–ØBo^ø¥*’¤ZÌ `Í“™ùpŽúd­Õ
 £Fjw¾: *®µuìF|š‰	ªL“Ue¬òÁ#æ e¬CtÁåYG‡°ãWó�	
>°ÓU™Qšçó! ¯0€¼±ÝX—ÈôHOTn…�³´	:
:U(ŠÑ4…ÔW	 c ,³†ë8¡"C÷Ý	ó	
}
”
Ý
¸>Êè`s¥Äzˆ¥  d}Ç�Ýíð¨	K
]ï4€y°Ö$-¤ ÝQdí-& KTÎ?rÉ5P¸U]rí=™dÜàjCg‚�«ÇuNÊl³}iØó m .ˆ63 V
—ª(àäÜIªö0FÔ!š ¨ !š»¹½¾}•1«çÙ]~ª 7 ï g6Íï)4m®œ	¥	Á	)
[
ñon‰ãµ©kŽ•ú! ™ é ö Xq}¦ù(’³ý—ô«qñÿ×	hQ<Ö@r)~N)é \ ^ ÷ùòkÆ ¼ë{
‚
„
’
Û
ü€Ž2‘“Ú¢' Ó ÝÑÝIYËáô”[Oã® ` „Ä+ÉñÔ×û	zÜŠ›’6:ŸáÑZ çÊØÔû‹"–
/;†
ƒŸ­C×9U¯3TÊ“ t Ä jå‹ôv÷üPzŒˆ/Ý0S% ¤ ÏŒ”¢#(IÇôýº|%¸
Á
 	|È#Âqã'):‰ã¤üð! 2 Q X ± É I^Æ@“–¡‚~	jþ"PM»äÁ
Ø�ä†Ca›, : ÆæVaeàï1gt¾K¾ÉÛèþ	‘r´1V–$IQXÙ"�J=g8â µ » ˜m7»n	 	�
Àãö–Ä =E‚¤Ä	nÇÄ]´ A q ú ŒR“Å{	±	ð	Ì
!§.F+L !ŠýR¿yÓ	¥j†…'²Š E ƒ 'AÞ0
WšÓI GÁj¬�\	O
ùÆÍücÎÓáëú»•¼ z^í	u
lìzÝó.­( { =�ì9`
k
-BéÉ=|¸aå  *‚ä.) 6—¶
þ
zO{’ôgñQ à (#%kª‘.
ßê[aðò ó þ ¸öO\:ŒC!
H
vœG%¸àTÒ7þx{�¦° M ßU&Â
á×aX›îKPž˜¶ç6AcÙ°&²ëä‡ Õ â B¼íKa<\kôƒ	ƒé·°¼Huejt + ˆ 9Ô$Exx´Ð7	ó ÂF‘¢ ;M¡Â	4ag _€¥äVc’¯]i¤«ñv‘~Ë b Í>qÈ|ÜÜìó<mÜ	9
J
·9'ªÆ„tVÕ£ÿc×¤  ˜ è î õ p¥ø‘²ü-5‡ºÌ5pð›	Ö	(
ˆHªjÓ\}© [ ÃÖ.ú	ÜžÖÛ18š59¡É’ £ Ã Î“ÈÚ$	Ç"óOPºâöûO	9I/<B`f ´ º QDQm	z	Ÿ	Œ
Ë
„±³ D ‚  ]Ýì	N
_
j
t
ò-™ÍÒà '” ò ý -TŸ-
uyßéO�µ5b¯±êãðz†� 8A»^Ljó‚	èò£ðGu�Ê
 Â p�ÂÇ¹ËëÙÕ	'
8
¶Æ�7NÔ48i¢.b¨ � ºl	y	�	ë	,
^
i
txçÞÌß°é“	…²' Á oÆË	Ì	&
7
opqrs³´µÅç›œn” 0123p¡ËÞ"pq# Ÿ6ŸÞ™,Ñ$	*	7	L	Í	@
è
oe•!Œr·Ðq9#rÕ Ì %	C	Î	A
éIœý9fŠÌ†¿ïýõ:¹±Þ šª«	w"!¾>mqÿs% =	1ÒSŽÂ@E�+	8	è	#
x
X-˜p"%xÉ+¸Ñ§r$C®" 1† 7 ß-ì.	3	M	s	ý	Ož|ïÝk–�«`fs”|lÊÖ  ˆÖw`	
B
êJeÅ‹5‡Àðöº²   W¾Ôu·Œ	�µÙ{:gb;ß éÙ69á‘ƒ…úC;XN\_Æí i Í Xª)&	;	D	»	Ï	°ýðþÍjvþe  ' ýÕ±ˆ
Ï
…Ýõ�šÁGë"„*´rÌ ‰ 
v«Øþ|¸Ô9›¶«T	
Ç
ô¡E£BÔ]²å†7pÁt áU·=EgZx¾BR}ƒ§?nê@ž¡d— –gzá(˜¬	
J]#¥ínŸ2Û”¿¢Væ' 0 5 O ¯ 3Ö>
 2ipAÒ1Fžy
�•ïmæq&2WÛâ|1{%D I!ÎŸ$T€�ÃA•¹Z	
y,hsé5ü ÌÚ3,	é	ø	$
™Ô#ÊM^F¨
n¼d¯Èýj  % §1�ÓÙ9	
Å
Y.>H4¼�¹Òé[(¿• 2ó�ÿt	1FP[0}¯Œ— a•±8íwÁË ¡¡©àéC„�â	þ	Ÿãcl¯;¬¸MBªó÷Ù 8€.¤§ÛÞí!	4	ð@SÞ¬Žg�fÈà¶¾m   T ‡Ðƒ`“,áÄ/	N	h	›
¤
ä
í
$9Ò÷t�»R}˜×  × ™Ø‡cça	Õé4,™¶AÁwlv³  ‰×kNx0¥ëÆ“Œ¾§÷ÈTž D¾l�
�È	
•±ÑëK€•ª²ñ:Tš*y®» ¨äÖäH	…	C
2KfÓx{Ž+†Ê¡6ˆŽ¾¦Uk x ƒ‚ÕÙv…ÉY¶º.`¹‘,�–ÑŒ\ XÞp
,©ìTÍ;Q�¸Û  Ð w&>v	ÚFúh.gƒÃà ! � cc¿^¸�	¨æž(|DLc<X—(^XO „	æýxÚ:³â †ÈYOî €Mê4a¯	ÀxRú ¿ æ 6éA	Ú	æ	í¨’ù„pû—<7`Ç¬ t©ü¶çR	7`DV]nì v Î ä 4®çÊâön
Ñþ´=?J”�Í =  Lé*Ùø'‰ö± ÿÌLÕ2Ü;Ï& j Æ YÄ»m«		'	6…k˜Úô¢þ	[ckw|?Š ÍÞÿ,ß!�ŸYÎ+ P\j’ïõ�°Ì		<	E	¼	Ð	'3<HR]‹u‘ ñ	OqtžÎ!³1fï!ƒ  nza~Y|Ÿ
¨
¬
×
è
ô
ü)‹Ä9ÞöžÂÎó[lH+Š Ü +ðZëJf°
ø
~¡^¼Hˆ¢CN¬×Í� ( J Ñ!Buè& %�¼Ö‰
LìÏí…ƒù$ÞÛ$ –þQ³²Ì^¯ú	Ð
ñ
†Îø±å%›è#or@+µÀÄsö � ’ Ùé£w Ñò·ÃöÿS¬aU	õ¢¥HC<^‡<Â! | Ïâ:¤*KœÉ“	 
c
º
Êõ	=¤àë5³¦%3=À -   w•¬ÿ}¹N¶vÈ
bsþF¨Õæ‹¸qu Š `Õï�÷


Ó
[S×²:Oå4€8ö ¦ &b•Žr¸z€¿
bh"A[¿S~Ø¨“�ë˜ ? &;ŠâûZ�£„µÄDþˆe¤ ì n£°ú,>ÛVåš)ð+@oA¢ƒÓ$ ÖGVz´Ògu‘~Ð'f	¹	Ã
7Fe®³óy[C0@yõLŸ —çÈ?	­	ä	%ä¾^Ü\•�WR ›|Y¦®°îº3†Ñ ÊFh9]ü)	
$o ivÄçùê «Ì’­tëEX{†â™ˆ	K¢nÒÀ"£òå( S4O°·ÆT\!Wq–BöG„²
Tßçr‰3¤ÃÓykx#|, 6 l W ™3­2ŸÀ	Z
g–ðn¸m½Õ'q(æ}MEùè! ×ÈÓöjŠÅð»Ó	Ðz
‚¬ûBX‰�‘®à2&Ð, 1 P W ° È ÅHU`dî0?Hf•½äüJ�iÁ!U~•LW&(y‹œ.Üãˆâû ù <�£Äº	¿-imÆÃ 8iœ[	,AkÜè·ê  ·õ["j%‹�B–
 
G
›FNÖ$šz`@%6ý ‡ :Jw³Ï; U	‘®Ÿ»ÁtdE Z — Ì={ÍÛ4Ûoï
	š	ù	Û8òN‡ÕOÅÚsG©þe ³ @,KSèN¢4atÉ" ž5Ý˜Ð
#	)	6	K	k	€	Ô	ê	%
²Äšmæ¶ÏhoÊè!’o Ë ~0©Áëœ-	2	Ü$w‰Ë_e¾ô½l¸°þk ‡½t©¶:	‹	
 Äü5àiu~„[ì" & •f¶Ôà
Æ
I½A¤ì mž¢AÓÚê\ƒ“)¡é6�Àc– $ 4 02Õ2@”¸Y	÷	Ž”l1g]Œá	c¾i(  S ¨òB‚_Ž£¦ÚÝþ+à 	£
ì
0EZÑ/?Rö®€ŽºQ©òvµÀ §ãj†Mb/G	Ô1~”°3�Ð…˜ ½¦9S¥Ç
xj  œ ‚vu	„§X'SùCW–'ÐÂ[Ú
 3åQ	w²_ùU, < 3O[iôŽÃK 		&2;GQ\Š5tj—Ùóps¡b Ÿ²+ “îÛ€Í:Ì) I Û  çYP`�²eË®	ž
§
Ö
ç
ð
K °$çòkì‚«¿Ãø#Ú _”è¢ÎávñÂ’	ÿ	¤GRÖ<9N;õ %m‰¢a¯ù”úq³�YÏ¸	6Uaäd™@ZCxô?œ ÉªE‘š¬sêD\…æû Ç>	ã	ã¡mÑ­¹huœ…éä& V R¯¶cÒí/G[I‰•ÄõÏ¿	«·AT”KV�Ò'x�›­Láç  ô9hvŠ›	
F
+@¾Û¶Â$ +}/¨ÏÀêî"	1	5	j	Ó	ñMvµ½3ógÉ·n ¼�¥ÜßµßŠ	�“ß­fhƒñ¿  NhÂâi…a.ä	P	%:Ó“&±øV&RTiÙ* $^lˆÈ®øDu«æ X²Á±åXÆ‘	�
¦
æ
ï
5JT`˜?QÐÕ�›~›èô  U ó»gÑZHˆ”Ã‰ÞôÎ	0	i	¾	Ò	
*?¶&w‚š¼*  fgñò­÷„ÀÂä-ÝâãÅO	�	œ
¥
å
î
)>_Ô#$%uvS€™šØ  -®  qGACNNNNNNGTC,CCAGGCCTGG,GATCCGGATC,CCWGGTACCWGG,CCANNNNNTGG,CCAGGNNNTGG,CCANNNCCTGG,CCAGGNCCTGG,GCACNNNAACGTTNNNGTGC,CACNNNGTG,CCNNNNNNNGG,AACNAACRYGTGCGTGC,GCACGCACRYGTTNGTT,GCACNAACRYGTTNGTGC,AACGCACRYGTGCGTT,GACNNNNNGTC,GAANNNNNNNTTGG,CCAANNNNNNNTTC,CACNNNNGTG,AACACNNNNGTGC,GCACNNNNGTGTT,GCANNNNNNTGC,GAACNNNNNNTCC,GGANNNNNNGTTC,CAGNNNCTG,CCAGGNNCTG,CAGNNCCTGG,CCWGGGCCC,GGGCCCWGG,CCWGGGCCCWGG,AACNNNNNNGTGCACNNNNNNGTT,GACNNNGTC,GAANNNNTTC,CCWGGTACC,GGTACCWGG,CCWGGWCCWGG,ACNNNNGTAYC,GRTACNNNNGT,CCWGGYRCCWGG,GAAGNNNNNNTAC,GTANNNNNNCTTC,AACGGCNNNGTGC,GCACNNNGCCGTT,GCACGGCNNNGTT,AACNNNGCCGTGC,CGANNNNNNTGC,GCANNNNNNTCG,CGATCNNNNTGC,GCANNNNGATCG,TGANNNNNNTCA,TGATCNNNNTCA,TGANNNNGATCA,TGATCNNGATCA,AACCTGCNNGTGC,GCACNNGCAGGTT,GCACCTGCNNGTT,AACNNGCAGGTGC,GCCNNNNNGGC,AACNNNNNNGTGCMC,GKGCACNNNNNNGTT,CCWGGNCCWGG,AACTGGGNNGTGC,GCACNNCCCAGTT,GCACTGGGNNGTT,AACNNCCCAGTGC,GACNNNNGTC,GAGNNNNNCTC,CCWGGTCTC,GAGACCWGG,GATNNNNATC,GATCNNNATC,GATNNNGATC,GATCNNGATC,CCWGGCGCCWGG,ACNNNNNCTCC,GGAGNNNNNGT,AACNNNNNNGTGCAG,CTGCACNNNNNNGTT,GATCATGATC,CCWGGNNCCWGG,AACTGGNNNGTGC,GCACNNNCCAGTT,GCACTGGNNNGTT,AACNNNCCAGTGC,AACNAACCGGTGCGTGC,GCACGCACCGGTTNGTT,GCACNAACCGGTTNGTGC,AACGCACCGGTGCGTT,GCANNNNNTGC,GCACNNNNNNGTTCGAACNNNNNNGTGC,CCTNNNNNAGG,GCNNNNNNNGC,CCANNNNNNTGG,CCAGGNNCCTGG,CCTGGCCAGG,CAANNNNNGTGG,CCACNNNNNTTG,TTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAA,GCACNNNNNNGTTTAAACNNNNNNGTGC,CCAGGNCCY,RGGNCCTGG,CCWGGGNCCTGG,CCAGGNCCCWGG,AAGNNNNNCTT,GAYNNNNNVTC,GABNNNNNRTC,GAYNNNNNRTC,GATCNNNNVTC,GABNNNNGATC,GAYNNNNGATC,GATCNNNNRTC,GATCNNNGATC,GTYAACNNNNNNGTGC,GCACNNNNNNGTTRAC,GCACNNNNNNGTTAACNNNNNNGTGC,GATCNGATC,TAACTATAACGGTCCTAAGGTAGCGA,TCGCTACCTTAGGACCGTTATAGTTA,CTCTCTTAAGGTAGC,GCTACCTTAAGAGAG,TAGGGATAACAGGGTAAT,ATTACCCTGTTATCCCTA,GTTAACNNNNNNGTGC,GCACNNNNNNGTTAAC,AACNAACGCGTGCGTGC,GCACGCACGCGTTNGTT,GCACNAACGCGTTNGTGC,AACGCACGCGTGCGTT,TCCAACNNNNNNGTGC,GCACNNNNNNGTTGGA,CAYNNNNRTG,AACAYNNNNGTGC,GCACNNNNRTGTT,GTTTAAACNNNNNNGTGC,GCACNNNNNNGTTTAAAC,CCWGGCGCC,GGCGCCWGG,CCWGGNNCC,GGNNCCWGG,GATCGCGATC,AACNAACATGTGCGTGC,GCACGCACATGTTNGTT,GCACNAACATGTTNGTGC,AACGCACATGTGCGTT,TGGCAAACAGCTATTATGGGTATTATGGGT,ACCCATAATACCCATAATAGCTGTTTGCCA,ATCTATGTCGGGTGCGGAGAAAGAGGTAATGAAATGG,CCATTTCATTACCTCTTTCTCCGCACCCGACATAGAT,AACNNGCACGTGCNNGTT,GAACNNNNNCTC,GAGNNNNNGTTC,CCAGGWCCY,RGGWCCTGG,CCWGGGWCCTGG,CCAGGWCCCWGG,CCAGGWCCTGG,TTATAACNNNNNNGTGC,GCACNNNNNNGTTATAA,GCACNNNNNNGTTATAACNNNNNNGTGC,GAACNNNNNNTAC,GTANNNNNNGTTC,GGCCNNNNNGGCC,AACNNACTAGTGC,GCACTAGTNNGTT,AACTAGTNNGTGC,GCACNNACTAGTT,AACNAACTAGTGCGTGC,GCACGCACTAGTTNGTT,GCACNAACTAGTTNGTGC,AACGCACTAGTGCGTT,AACNNNAACGTGCNNGTGC,GCACNNGCACGTTNNNGTT,GCACCCANNNGTT,AACNNNTGGGTGC,TTAACNNNNNNGTGC,GCACNNNNNNGTTAA,CACNNNNNNTCC,GGANNNNNNGTG,CACNNNNGATCC,GGATCNNNNGTG,GATCTAGATC,CCANNNNNNNNNTGG,CCAGGCCT,AGGCCTGG,CCTCGAGG,GATCCGGA,TCCGGATC,GGCGCGCC,GCGATCGC,CCWGGWCC,GGWCCWGG,GATCGATC,GATCATGA,TCATGATC,GCGGCCGC,CCTGGCCR,YGGCCAGG,CCWGGNCC,GGNCCWGG,GGCCGGCC,RTGCGCAY,GATCNNGA,TCNNGATC,CGCGCGCG,CCTGGCCA,TGGCCAGG,CGCCGGCG,GTTTAAAC,GATCGCGA,TCGCGATC,TTAATTAA,VCTCGAGB,CCTGCAGG,CRCCGGYG,CGTCGACG,ATTTAAAT,GCCCGGGC,GATCTAGA,TCTAGATC,CACCTGC,GCAGGTG,CCTNAGG,GATCGAT,ATCGATC,CCTCAGC,GCTGAGG,GCTNAGC,CCTNAGC,GCTNAGG,GCTCTTC,GAAGAGC,GGTNACC,CGGWCCG,ACCWGGT,RGGNCCY,CCTGGAG,CTCCAGG,GGTGATC,GATCACC,GATCNGA,TCNGATC,GGGWCCC,GAAGATC,GATCTTC,CCCWGGG,TCCNGGA,TCCWGGA,RGGWCCY,TTATAA,AGGCCT,GACGTC,GTMKAC,TCCGGA,TGCGCA,ACCTGC,GCAGGT,GGTACC,AGTACT,GGYRCC,CCGCTC,GAGCGG,AACGTT,YGGCCR,RAATTY,CTGAAG,CTTCAG,CACGTG,GRCGYC,AGCGCT,CTTAAG,ACRYGT,ACCGGT,ACTAGT,CACGTC,GACGTG,GWGCWC,GTGCAC,CYCGRG,GGGCCC,ATTAAT,CCTAGG,TTCGAA,GCTAGC,GKGCMC,TGGCCA,GGATCC,GRGCYC,ATCGAT,CACGAG,CTCGTG,GGCGCC,GAAGAC,GTCTTC,GCATGC,GTATCC,GGATAC,TGATCA,ACTGGG,CCCAGT,CTRYAG,RGCGCY,AGATCT,GGNNCC,CTGGAG,CTCCAG,CTTGAG,CTCAAG,CGATCG,GGTCTC,GAGACC,YACGTR,CCNNGG,GAATGC,GCATTC,WCCGGW,GCAATG,CATTGC,RCCGGY,GCGCGC,GAGGAG,CTCCTC,CGGCCG,CCCAGC,GCTGGG,GTGCAG,CTGCAC,CGRYCG,CGTACG,CGTCTC,GAGACG,CCATGG,TCGCGA,GDGCHC,TGTACA,TCATGA,ACATGT,GTATAC,CCWWGG,CTCTTC,GAAGAG,GCNNGC,CCRYGG,GTTAAC,RCATGY,TACGTA,RGATCY,GCGATG,CATCGC,GCAGTG,CACTGC,CCCGGG,CCGCGG,TTTAAA,GGCGGA,TCCGCC,GAGCTC,GATATC,CTGRAG,CTYCAG,CAGCAG,CTGCTG,GAATTC,ATGCAT,CATATG,GTYRAC,AAGCTT,GTNNAC,TCNNGA,CAATTG,ACGCGT,TCCRAC,GTYGGA,GCCGGC,CMGCKG,GCCGAG,CTCGGC,CTCGAG,CTGCAG,CAGCTG,GTCGAC,CTYRAG,AATATT,GATCGA,TCGATC,GACCGA,CACCCA,TCGGTC,TGGGTG,WGTACW,TARCCA,TGGYTA,TCTAGA,GGATC,GATCC,CCWGG,GTCTC,GAGAC,GCWGC,GGNCC,CCSGG,GGTGA,TCACC,GGWCC,GCAGC,GCTGC,CCATC,GATGG,ACGGC,GCCGT,GCNGC,CCNGG,GCATC,GATGC,ACTGG,CCAGT,GGATG,CATCC,CTCAG,CTGAG,GGGAC,GTCCC,ACNGT,CTNAG,CAGTG,CACTG,GACGC,GCGTC,CCCGC,GCGGG,GANTC,CGWCG,TCNGA,CCTTC,GAAGG,GTNAC,GAAGA,TCTTC,GAGTC,GACTC,GTSAC,GAWTC,GCSGC,CASTG,ATGAA,TTCAT,ACGGA,TCCGT,CGCG,CCGC,GCGG,GTAC,AGCT,GCGC,CTAG,GATC,GGCC,CCGG,CATG,RGCY,YATR,ACGT,TGCA,AATT,CCTC,GAGG,TTAA,ASST,TCGA                                                                                                                                                                                                                                                                                                                                                        ,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
                           	                                                                           	                                                                                                                                 )                                            	                                                          	                                                                                             
      
            -   "      	                                 	   	                                    	                                    ,         $   "      !            {   Q      %               Y                                                                                                                                                                   ,                                                                                                                                                                                                                                                                                             
           	                           	                                               )                	                    	                                 
  
    - "  	           	 	            	            ,   $ "  !    { Q  %     Y   n†  o¼  oÜ  p  t<  xº  ~¤Ø	¥=­	$ušghsZ[�\�”åÎ
¥
\w—°9çùŸ¶O2M¯
÷
Þ	J ZrËLq
§Xä)MÇÆæ†)ÿÿ‡Þ	D¯)õ¹
¾ MÇçkƒ)AJ_±¿õƒ›ØÚ		=	¢
¹
4ƒ‰�Õìw}òEPÑýQ”BÆ[}²¯ Ín<O™„nw4<ZOn<On<„n<íb™ALëR¯ž
ç
ò²Šß	Õ²¯†¬³[]¶³ òÛä 3
[]sìëE² \í¿“Õ
²D…†xíˆêïÁDaºû”—²D-
é»r§ú´ê ÍžZaíô0ìF“U(~£2Ê~£ÞVü†	�²× 	ó¡)’›5ª]2àg‚6Ø~ :Pf

½æþr§ú´å�Mœlê¹ã ×ø -„/¦ý»šïï…atÓ†ÿ \s
ñ,ÿ¾9ß†V³ï]àŠ�-„/†¦‘µù^à„ì�qy¾
!Á`¨Ÿ6®ñSæ J�jw�ÐÁàŸE¹		�YË Ê~Š£²ÞVDE�†üq	†	¡
ê
�²×õ ~§zÈBÃ®©GA\ÀÃqm‹—K­	¾a¯Z`„…†a”•-ô�
¦
æ
a„¾Ó3@Òw(¯¥8wrŠ@¦F	Ï„Ÿ¤æ«£ÚÝ2±ï
Vƒ±ˆ"2€(ÃXÚaa@Í -„/ß†¦‘µV³ý»ùšï§—×Zaa¾@]ií¿w MÐb.OSæþy¨Ê{		F	«
¾
ó
$Þ¹û!JN„Ÿ#�æ;Âaa@y¾
!×K Š�ì;1¹Xc¹ÅÅÖÏ EV'¹	®$ÝF$ù…aÓÌß“£‘ó�1FP[±í-„/¦B½Ãæ®©þñ
o@ã:P
{À
â ç aíx ç ²ÀèÍžª	á	ò	Zaùïí  Í 3 «A€Ÿô¡Ýæ9q�÷]ÀF¨
]§ª—  ã •Ma ÕÛ	F	„ŸÃ–Q¯ø%+ ÍƒWÏtÁ–Q¯ø% aítAG\ÀvÙš ¥AYò
º¯:Š) Ò"Cv25ðK
«ïí€ Š�ì;1¹X¹Å ‹Î‚ŠªdÆ–×R¯¶[`•õž
§
Ö
ç
Òòkx¦ŒØ”qm‹Úø—Ç T_•e”¼ãùhÍ÷ } ä'xŠ-nq?‡õØ L©³¹pEY†‡µ	”~ÍÞ¼âi…†ab.ÓÔ“3˜R
ie£	.zá˜J¿¢³E”Þ¼•ùÍ÷ änq?õÇ T_e”¼ãh }'xŠ-‡³�Ï¸	6dZxô¦	È„	*½2v; Ç T_•e”¼ãÕãù‰4hsÍÒ÷ wz}iÉò rä'xŠ�ž-nq?‡ÚõT9R¯¶â[`i…†ab•.õž
§
Ö
ç
ÓÔ“3˜ÒòkxR
ift}&e	Â

²ò/K8 h\‰poGN
Sjw+I  ç�Kì‚ø#ÚˆþÇà¦‘f	7@õ& Ôêƒ)l 2Ÿ–'Eš1Ù²D-šš
ã
#C½%ºÇ	
~ê^±øÎ
& l ³ Ô2Ÿ–'êƒ)Eè %�…ƒÞF$oivùþ¬Mœ=æmNhÂ	%:æ+µ@" ¬ “drß	õ	uû/iŽ2s¾JO^æ(7L`<V]ìï5 ˆÖ2w1žt	•êïmÅ&‹G•ö|ÁÌD}/¨Àê1	v½ó·>ßšùÉÊ.7Žë—òþ	;ñ<{ï
U�(ä© £¦qí¿a,	#Ê^¼¯ýjß	J" “drõ	/sO—þ	;U(¬ uûiŽ2¾; Õã‰4sÒwziÉòr�žÚT9Fè %�$oiv…ƒÞù§ ¼|0Øw>m Sv Î ä 4®çÊâön
Ñþ´=?J”�Í< 3O[iôŽÃK 		&2;GQ\Š5tj—Ùóps¡b Ÿ²+ “îÛ€Í:ÌkŒ	Œ¤ÕãæÒwz’É+µ@J�”©™)­T�* Ô Óì#Dw¤ãbÁ3… .y…Ó0S—±ôÿRU´§°W	X
™ÏÙùÃækq‡æ&œ~t³u Å ¯ºæèËØá÷		ˆ�Ðõÿ³ý>Z{‰Ì0ÞKÔ1‚Îù <�£Äº	¿-imÆÃ   ‹7Îxn‚¯íò<ŠÛä2ªºYdlºÆ/„–ÄÆ×ûÙ L©¹q^Z‡¶	D
‚ˆ¼3áhƒ7åð´~ÎÙ§ãj†Mb/G	Ô1~”°3�Ð…˜ ½¦9S¥Ç
xj¦ &b•Žr¸z€¿
bh"A[¿S~Ø¨“�ë˜G … • Ù "LU.6Qy…©¹Óþ0Sq—±ôÿ-NR^dâUZ´ÀÍî>‡§³Í’š°¶I	W	¶	D
X
¡
ê
e‚ˆ™°¼ÂÏÙ3DLg€ÔÝáùk|�Îúhƒ‡¬ÃÓ‡¢ækq‡»Ðæ&7‰œåð~$s´¿êr~§ÁÅÎjt³Ù ? ¦ à &(*;‚Šâä&.b#%k•û)Ž ª6r¸Zz‘€—.
¶
¿
þ
bzßOh�"A[£{¿êS[~„µÄØa’¨ðòôDg“�ëñþQˆe˜¤s¨ûLµè`@	®	Ù	å	¿–6«ë¤ ÏŒ”¢#(IÇôýº|%¸
Á
 	|È#Âqã'):‰ã¤üð ¡ [O�·;3Q"g
r
v
É
m˜©ôÐ¼�¥ÜßµßŠ	�“ß­fhƒñ¿e ÂE„h¡€†«®ºBÊ/GJŽoD ‚  ]Ýì	N
_
j
t
ò-™ÍÒà '”f … s¨û*Lµ.y…¢®µÓ0Su—±ÃìôÿFR|Uœ´è`š§û8°@	W	‰	®	Ù	å	X
Ø
™ÏÙ*ªùL“¿ÃU�æekq‡æ&œK~¬ä÷�ò–Á#6t³«æë  W¾Ôu·Œ	�µÙ{:gb;ßî   -<AlignableSequences trimStringency="Medium"/>  !<AdditionalSequenceProperties><UpstreamStickiness>0</UpstreamStickiness><DownstreamStickiness>0</DownstreamStickiness><UpstreamModification>FivePrimePhosphorylated</UpstreamModification><DownstreamModification>FivePrimePhosphorylated</DownstreamModification></AdditionalSequenceProperties>
  "ô<?xml version="1.0"?><Features nextValidID="17"><Feature recentID="0" name="RNF144A" directionality="1" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1908" maxFusedRunOn="1908"><Segment range="919-1872" color="#ffcc00" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MTTTRYRPTWDLALDPLVSCKLCLGEYPVEQMTTIAQCQCIFCTLCLKQYVELLIKEGLETAISCPDAACPKQGHLQENEIECMVAAEIMQRYKKLQFEREVLFDPCRTWCPASTCQAVCQLQDVGLQTPQPVQCKACRMEFCSTCKASWHPGQGCPETMPITFLPGETSAAFKMEEDDAPIKRCPKCKVYIERDEGCAQMMCKNCKHAFCWYCLESLDDDFLLIHYDKGPCRNKLGHSRASVIWHRTQGSTLSPSLGRSTPPSRPSSCSSPCGKPFSVSSSPHVWLLGNHSALYFLMQDYKCVYHSPELSIGSGGQK"/></Q></Feature><Feature recentID="1" name="HA" directionality="1" translationMW="1102.21" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" maxRunOn="1908" maxFusedRunOn="1908" originalName="HA" originalSequence="TACCCATACGACGTACCAGATTACGCT" isFavorite="1" detectionMode="exactProteinMatch"><Segment range="1879-1905" color="#cc99b2" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;HA (human influenza hemagglutinin) epitope tag&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="YPYDVPDYA"/></Q></Feature><Feature recentID="2" name="AmpR" directionality="2" translationMW="31558.16" type="CDS" swappedSegmentNumbering="1" allowSegmentOverlaps="0" cleavageArrows="6179" readingFrame="-1" consecutiveTranslationNumbering="1" hitsStopCodon="1" detectionMode="exactProteinMatch"><Segment range="5388-6179" color="#ccffcc" type="standard" translated="1"/><Segment name="signal sequence" range="6180-6248" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to ampicillin, carbenicillin, and related antibiotics&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;Î²-lactamase&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MSIQHFRVALIPFFAAFCLPVFA,HPETLVKVKDAEDQLGARVGYIELDLNSGKILESFRPEERFPMMSTFKVLLCGAVLSRIDAGQEQLGRRIHYSQNDLVEYSPVTEKHLTDGMTVRELCSAAITMSDNTAANLLLTTIGGPKELTAFLHNMGDHVTRLDRWEPELNEAIPNDERDTTMPVAMATTLRKLLTGELLTLASRQQLIDWMEADKVAGPLLRSALPAGWFIADKSGAGERGSRGIIAALGPDGKPSRIVVIYTTGSQATMDERNRQIAEIGASLIKHW*"/></Q></Feature><Feature recentID="3" name="NeoR/KanR" directionality="1" translationMW="29048.78" type="CDS" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1" hitsStopCodon="1"><Segment range="3089-3883" color="#ccffcc" type="standard" translated="1"/><Q name="codon_start"><V int="1"/></Q><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;aph(3')-II&lt;/i&gt; (or &lt;i&gt;nptII&lt;/i&gt;)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;confers resistance to neomycin, kanamycin, and G418 (GeneticinÂ®)&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="product"><V text="&lt;html&gt;&lt;body&gt;aminoglycoside phosphotransferase from Tn5&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="transl_table"><V int="1"/></Q><Q name="translation"><V text="MIEQDGLHAGSPAAWVERLFGYDWAQQTIGCSDAAVFRLSAQGRPVLFVKTDLSGALNELQDEAARLSWLATTGVPCAAVLDVVTEAGRDWLLLGEVPGQDLLSSHLAPAEKVSIMADAMRRLHTLDPATCPFDHQAKHRIERARTRMEAGLVDQDDLDEEHQGLAPAELFARLKARMPDGEDLVVTHGDACLPNIMVENGRFSGFIDCGRLGVADRYQDIALATRDIAEELGGEWADRFLVLYGIAAPDSQRIAFYRLLDEFF*"/></Q></Feature><Feature recentID="4" name="ori" directionality="2" type="rep_origin" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="4629-5217" color="#ffff00" type="standard"/><Q name="direction"><V text="LEFT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;high-copy-number ColE1/pMB1/pBR322/pUC origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="5" name="f1 ori" directionality="1" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2250-2678" color="#ffff00" type="standard"/><Q name="direction"><V text="RIGHT"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;f1 bacteriophage origin of replication; arrow indicates direction of (+) strand synthesis&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="6" name="SV40 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2692-3022" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 enhancer and early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="7" name="bGH poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="1980-2204" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;bovine growth hormone polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="8" name="CMV promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="615-818" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;human cytomegalovirus (CMV) immediate early promoter&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="9" name="SV40 ori" type="rep_origin" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="2873-3008" color="#ffff00" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 origin of replication&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="10" name="SV40 poly(A) signal" type="polyA_signal" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="4057-4178" color="#a6acb3" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;SV40 polyadenylation signal&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="11" name="AmpR promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="6249-6353" color="#ffffff" type="standard"/><Q name="gene"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;bla&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="12" name="lac promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1" visible="0"><Segment name="-10" range="4275-4281" color="#ffffff" type="standard"/><Segment range="4282-4299" color="#ffffff" type="standard"/><Segment name="-35" range="4300-4305" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for the &lt;i&gt;E. coli lac&lt;/i&gt; operon&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="13" name="CAP binding site" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1" visible="0"><Segment range="4320-4341" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;E. coli&lt;/i&gt; catabolite activator protein&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;CAP binding activates transcription in the presence of cAMP.&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="14" name="T7 promoter" directionality="1" type="promoter" allowSegmentOverlaps="0" consecutiveTranslationNumbering="1"><Segment range="863-881" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage T7 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="15" name="SP6 promoter" directionality="2" type="promoter" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1"><Segment range="1936-1954" color="#ffffff" type="standard"/><Q name="note"><V text="&lt;html&gt;&lt;body&gt;promoter for bacteriophage SP6 RNA polymerase&lt;/body&gt;&lt;/html&gt;"/></Q></Feature><Feature recentID="16" name="lac operator" type="protein_bind" swappedSegmentNumbering="1" allowSegmentOverlaps="0" readingFrame="-1" consecutiveTranslationNumbering="1" visible="0"><Segment range="4251-4267" color="#31849b" type="standard"/><Q name="bound_moiety"><V text="&lt;html&gt;&lt;body&gt;&lt;i&gt;lac&lt;/i&gt; repressor encoded by &lt;i&gt;lacI&lt;/i&gt;&lt;/body&gt;&lt;/html&gt;"/></Q><Q name="note"><V text="&lt;html&gt;&lt;body&gt;The &lt;i&gt;lac&lt;/i&gt; repressor binds to the &lt;i&gt;lac&lt;/i&gt; operator to inhibit transcription in &lt;i&gt;E. coli&lt;/i&gt;. This inhibition can be relieved by adding lactose or isopropyl-Î²-D-thiogalactopyranoside (IPTG).&lt;/body&gt;&lt;/html&gt;"/></Q></Feature></Features>
   —<?xml version="1.0"?><Primers nextValidID="0"><HybridizationParams minContinuousMatchLen="10" allowMismatch="1" minMeltingTemperature="40"/></Primers>
  §<Notes>
<UUID>add2544a-e8ae-43e8-88ef-6e948684c65c</UUID>
<Type>Synthetic</Type>
<ConfirmedExperimentally>0</ConfirmedExperimentally>
<CustomMapLabel>pCMV-RNF144A(human)-HA-Neo</CustomMapLabel>
<UseCustomMapLabel>1</UseCustomMapLabel>
<Created UTC="16:0:0">2016.10.12</Created>
<LastModified UTC="20:13:12">2025.9.20</LastModified>
<SequenceClass>UNA</SequenceClass>
<TransformedInto>unspecified</TransformedInto>
</Notes>
  Y     K         
?????                                                                                                       ÿ d      DO  P               E              ÿÿÿÿYô? P                                                                                                                                                              3<?xml version="1.0"?><EnzymeVisibilities vals=""/>
   )<?xml version="1.0"?><CustomEnzymeSets/>
